Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p306 | (1) | WCRB2014

Inhibition of the polyamine pathway induces an embryonic diapause-like state in the mouse embryo

Catherine Fenelon Jane , Banerjee Arnab , Murphy Bruce D

Introduction: Embryonic diapause is a period of developmental arrest in which the embryo is maintained in a dormant state for an extended period of time. Over 130 species of mammals undergo embryonic diapause, but the molecular control mechanisms remain unknown. In this study, we investigated the potential role of polyamines during embryonic diapause in the mouse. Polyamines play essential roles in cell growth and proliferation, and the regulation of their expression is contro...